kaleidoscopik

nakahira e16, originally uploaded by kaleidoscopikr.

The remarkable finding in the present study was the transient appearance of large numbers of EGFP-labeled multipolar cells in the SVZ and IMZ during E16-18. Their morphology has been described in the hippocampal primordium of the rabbit and monkey by the Golgi method, but their significance has not been adequately discussed. The presence of the multipolar cells in the SVZ and IMZ has also been reported in neocortical development. In our study, the multipolar cells accounted for 30.1% of the EGFP-labeled cells in the neocortical primordium of the mouse at E16. Their migratory pattern within the subcortical zone is nonradial and has been described as multipolar migration, as opposed to radial locomotion or somal translocation. The multipolar cells migrate slowly, at about one-fifth the rate of the bipolar cells in the neocortex. - nakahira and yuasa 2005